Then you didn't do it right. This works 100% of the time when you do it right. It's been tested 100s of times by every single mac user since apple updated their OSes and broke old software. The setting gets stuck, then desmume uses it when it boots up, and it crashes. if you correctly uninstall and delete everything, the setting doesnt exist anymore. You may need to find a friend who knows how to really work computers to do it for you.