Good to read that hint about --disable-3d, now I can play desmume again - more or less. I had the same problem with desmume crashing before it even really started (window was visible and disappeared quickly).However this doesn't work for the glade version.

I ask you to find another way to fix this issue. I can't really disable direct rendering to play a 3d game, that's paradox. And as much as I like desmume, this workaround is a no-go for me.