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When a game is running and I click off Desmume to interact with Chrome or another application, the layout of the LCD screens changes to single screen, instead of horizontal, which is how I normally have it.
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Are you sure you don't mean "Whenever I click off desmume, or don't click off desmume, really whatever it doesn't matter, and I press the "end" key on my keyboard, the layout changes to single"?
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No, as I'm not pressing the 'end' key, I'm left clicking on google chrome and it's doing that.
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uninstall any hotkey or gamepad managers or "system enhancement" malware; reboot your computer.
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